Which typical antipsychotic is most frequently linked with a high risk of extrapyramidal symptoms (EPS)?

Haldol, known generically as haloperidol, is a typical antipsychotic that is particularly associated with a high risk of extrapyramidal symptoms (EPS). EPS includes a variety of movement disorders, such as tremors, rigidity, bradykinesia, and tardive dyskinesia, which are significant side effects resulting from the blockade of dopamine receptors in the brain.

Haldol has a strong affinity for D2 receptors and is known for its potency in this regard, which is why it is particularly effective in treating acute psychosis and delirium. However, this same receptor blockade is what contributes to the higher incidence of EPS. Patients taking Haldol may experience these side effects more prominently than with other antipsychotics.

While Thorazine and Stelazine are also typical antipsychotics and can cause EPS, they generally have a lower risk compared to Haldol. Risperidone, on the other hand, is an atypical antipsychotic that typically has a lower incidence of EPS due to its serotonin-dopamine antagonist properties, which reduce the risk of these motor side effects. Therefore, Haldol stands out as the antipsychotic most frequently linked with a high risk