Which two second-generation antipsychotics can be prescribed for children diagnosed with autism?

Aripiprazole and Risperidone are the two second-generation antipsychotics that are frequently prescribed for children diagnosed with autism. Both medications have been studied and are approved for use in managing irritability and associated aggressive behaviors in this population.

Aripiprazole functions as a partial agonist at certain dopamine receptors and has a favorable side-effect profile, making it suitable for use in pediatric patients. It helps address symptoms such as mood swings and irritability, which can be particularly challenging for children with autism.

Risperidone has also been shown to be effective in reducing symptoms of aggression, severe tantrums, and self-injurious behavior in children with autism. It works by antagonizing dopamine and serotonin receptors, thereby influencing mood and behavior positively.

The other options consist of medications that either do not have as established a safety or efficacy profile in children with autism or are not FDA-approved for such indications. Therefore, Aripiprazole and Risperidone are the recommended choices for managing the symptoms associated with autism in children.