Which treatment is indicated for Cocaine dependence?

Bromocriptine is indicated for the treatment of cocaine dependence due to its dopaminergic properties. Cocaine exerts its effects primarily by inhibiting the reuptake of dopamine in the brain, leading to increased dopaminergic activity that contributes to its addictive potential. Bromocriptine, a dopamine agonist, may help mitigate withdrawal symptoms and reduce cravings by activating dopamine receptors in a controlled manner. This can assist in the management of cocaine dependence as it targets the underlying neurobiological pathways involved in the addiction.

The other options, while they have various therapeutic applications, do not directly address the neurochemical imbalances associated with cocaine dependence. SSRIs are primarily used to treat depression and anxiety disorders and have not been shown to be effective in treating cocaine addiction. Metformin is used primarily for the management of type 2 diabetes and has no established role in the treatment of substance use disorders, including cocaine dependence. Modafinil, while it may have some potential for addressing certain stimulant-related issues, is not specifically indicated for cocaine dependence. Thus, bromocriptine stands out as the most relevant choice for managing this condition.