Which TCA is known for treating enuresis?

Imipramine is recognized for its effectiveness in treating enuresis, which is the involuntary discharge of urine, commonly known as bedwetting. This tricyclic antidepressant (TCA) has been found to help reduce the frequency of nighttime urination in children and is often prescribed for cases of primary nocturnal enuresis. The mechanism by which Imipramine aids in this condition is believed to involve its anticholinergic properties, which can help decrease bladder contractions, thus increasing bladder capacity and reducing the urgency to urinate during sleep.

While the other TCAs listed have their own indications and uses, they are not primarily known for treating enuresis. Nortriptyline, for example, is often used for depression and chronic pain management, Amitriptyline is frequently employed for depression and certain chronic pain conditions, and Desipramine is mainly used for depression as well. Their effectiveness in treating enuresis is not supported by the same level of evidence as Imipramine.