Which SSRI is known to cause QT interval prolongation?

Citalopram is known to cause QT interval prolongation due to its effects on cardiac repolarization. The relationship between citalopram and prolonged QT intervals has been observed in clinical studies, leading to recommendations for close monitoring of this effect, particularly in patients who have preexisting cardiac conditions or are taking other medications that can affect heart rhythm. This concern is particularly significant at higher doses, where the risk of QT prolongation increases.

In clinical practice, it's important to be aware of this side effect when prescribing citalopram, especially for those patients who may be at greater risk of cardiac issues. Monitoring ECGs in patients on this medication who may show symptoms of arrhythmia or have risk factors for prolonged QT can help mitigate the risks associated with its use.