Which of the following conditions can worsen with the administration of antipsychotics?

The condition that can worsen with the administration of antipsychotics is PCP toxicity. Antipsychotics work by blocking dopamine receptors in the brain, which can complicate and exacerbate the symptoms resulting from intoxication with phencyclidine (PCP). PCP is an NMDA receptor antagonist and can lead to increased agitation, delirium, and psychotic features. When antipsychotics are given, they may not effectively address these symptoms and can even lead to increased confusion or exacerbated psychotic features related to PCP.

While antipsychotics can have varying effects on depression and anxiety disorders, these conditions are generally managed with appropriate pharmacotherapy that may differ from antipsychotic treatment. In cases of obsessive-compulsive disorder, selective serotonin reuptake inhibitors (SSRIs) are typically the first line of treatment rather than antipsychotics, which might not directly worsen OCD but would not be the most effective treatment option. Thus, the specific interaction between antipsychotics and PCP toxicity makes it the most concerning condition in this context.