Which mood stabilizer is associated with potential skin rash or Stevens-Johnson syndrome (SJS)?

Lamotrigine is a mood stabilizer that is particularly known for its association with skin rashes and the more severe condition called Stevens-Johnson syndrome (SJS). SJS is a potentially life-threatening reaction characterized by severe skin blistering and detachment, often accompanied by other systemic symptoms.

The risk of developing SJS is notably higher when lamotrigine is titrated too quickly, especially when combined with other medications such as valproate, which can increase its serum levels. It is essential for clinicians to be aware of this risk and to educate patients on recognizing early signs of rash while on this medication, as early intervention is critical in managing any potential adverse reactions.

Other mood stabilizers like valproic acid, lithium, and carbamazepine can have side effects and adverse reactions, but they are not primarily associated with SJS to the same extent as lamotrigine. While carbamazepine can also cause skin rashes, the specific association of lamotrigine with SJS makes it the most notable option in this context.