Which is a common side effect of typical first-generation antipsychotics?

First-generation antipsychotics, also known as typical antipsychotics, are well-documented for their association with extrapyramidal symptoms (EPS). These symptoms arise due to the blockade of dopamine D2 receptors in the nigrostriatal pathway, which is a crucial area involved in the regulation of movement. As a result, patients may experience a range of motor side effects, including tremors, rigidity, akinesia (slowness of movement), and tardive dyskinesia (involuntary movements).

These extrapyramidal symptoms can significantly impact a patient's quality of life. They differ from other side effects associated with antipsychotic medications, such as weight gain and metabolic changes, which are more commonly associated with atypical antipsychotics. While agranulocytosis is a serious side effect, it is typically associated with clozapine, an atypical antipsychotic, rather than first-generation agents. Thus, extrapyramidal symptoms are the hallmark side effects of typical first-generation antipsychotics, making this the correct answer.