What non-psychologic medication may be used to augment treatment for depression?

T3 supplementation, or triiodothyronine, is recognized as a potential augmenting agent in the treatment of depression, particularly in cases where patients exhibit inadequate response to conventional antidepressants. This approach is rooted in the understanding that thyroid hormones can have a significant impact on mood and overall mental health.

Research has shown that low thyroid hormone levels can contribute to depressive symptoms, and in some cases, administering T3 can lead to improved mood and diminished depressive symptoms. It is thought that thyroid hormones may enhance the efficacy of antidepressant medications by influencing neurotransmitter systems, particularly those involving serotonin and norepinephrine.

In the context of the other choices, calcium chloride is primarily used in cases of hypocalcemia or as a cardiac agent and does not have documented benefits for depression. Dantrolene is a muscle relaxant often used to treat malignant hyperthermia and spasticity, and does not address depressive symptoms. N-Acetylcysteine, while being studied for its potential benefits in various psychiatric conditions, does not have as strong or consistent evidence of efficacy as T3 for augmenting depression treatment. Overall, T3 supplementation stands out as a complementary strategy specifically supported in the context of treating depression.