What mood stabilizer is associated with an increased risk of pancreatitis and hepatic issues?

Valproic acid is the mood stabilizer linked to an increased risk of both pancreatitis and hepatic issues. The mechanism behind this association may stem from valproic acid's effects on liver metabolism and its potential to cause hepatotoxicity, particularly in certain populations, such as children or those with pre-existing liver conditions. Additionally, valproic acid can lead to an elevation in liver enzymes, suggesting liver injury, and there have been reports of acute pancreatitis occurring in some patients taking the medication.

In contrast, other mood stabilizers, while having their own side effects and risks, do not prominently feature pancreatitis or significant liver damage in their profiles to the same degree as valproic acid. For instance, lamotrigine is generally well tolerated with a different side effect profile, primarily related to skin reactions. Lithium is primarily monitored for renal function, thyroid function, and electrolyte balance, while carbamazepine is associated with its potential to cause blood dyscrasias, but not strongly linked to pancreatitis or serious liver issues like valproic acid.