What is the recommended overdose treatment for tricyclic antidepressants?

The recommended overdose treatment for tricyclic antidepressants involves the use of sodium bicarbonate. Tricyclic antidepressant overdoses can lead to metabolic acidosis and severe cardiotoxic effects, such as arrhythmias due to sodium channel blockade. Sodium bicarbonate acts by alkalinizing the serum, which can help counteract the cardiotoxic effects, particularly by stabilizing the cardiac membranes and improving the cardiac conduction.

By increasing the pH, sodium bicarbonate can also help to bind free tricyclic antidepressants in the extracellular space, reducing the concentration of these drugs and mitigating their toxic effects. This intervention is particularly effective in managing the cardiac complications associated with TCA overdose.

Other choices, while they may have relevance in specific overdose situations, do not address the primary complications arising from tricyclic antidepressant toxicity. For instance, calcium chloride might be used in cases of calcium channel blocker overdose, glucagon is primarily used for beta-blocker overdose, and Flumazenil is used to reverse the effects of benzodiazepines but can potentially precipitate seizures in patients with mixed drug overdoses, making it a risky choice in this scenario.