What is the primary risk when using Valproic Acid during pregnancy?

Using Valproic Acid during pregnancy primarily poses the risk of lowered folate levels, which is particularly concerning because adequate folate is essential for proper fetal development, especially during the early stages of pregnancy. Folate plays a crucial role in DNA synthesis and repair, as well as in the formation of the neural tube, which later develops into the brain and spinal cord. Insufficient folate during pregnancy can lead to neural tube defects and other developmental issues in the fetus.

While there are correlations with autism in children exposed to certain anticonvulsants, including Valproic Acid, the most direct and immediate concern during pregnancy involves ensuring the mother maintains adequate folate levels to support healthy fetal development. Issues related to gestational diabetes and increased blood pressure are not typically associated with Valproic Acid use, making the risk of lowered folate levels the most significant consideration when prescribing this medication to pregnant patients.