What is one of the potential side effects associated with chronic use of chlorpromazine?

Chronic use of chlorpromazine, an antipsychotic medication, can lead to corneal deposits as one of its potential side effects. This occurs due to the drug's ability to accumulate in the tissues of the eye, specifically in the cornea. Over time, patients may develop deposits that can result in visual impairment or discomfort.

Other options listed may not be typical or expected side effects associated with chlorpromazine. For instance, weight gain is more commonly observed with this medication rather than weight loss. Hepatitis is not a well-documented side effect of chlorpromazine, and while the drug may contribute to changes in blood pressure, hypertension is not a recognized side effect in the context of long-term use of this medication. Therefore, corneal deposits represent a significant and notable consequence of extended chlorpromazine therapy, making it the most relevant answer in this context.