What is a possible side effect of higher doses of Mirtazapine?

Mirtazapine is an antidepressant commonly used to treat major depressive disorder, and its side effects can vary depending on the dosage. At higher doses, one notable side effect that can occur is excessive sedation. This is because mirtazapine is known to have sedative properties, particularly at lower doses due to its antihistaminergic effects. As the dose increases, the sedative effect can become more pronounced, leading to excessive drowsiness or sedation in some patients.

This is an important aspect to consider when prescribing mirtazapine, as it can impact a patient's daily functioning and quality of life. Monitoring for excessive sedation is crucial, particularly in individuals who may be sensitive to this side effect or those who operate machinery or drive.

In contrast, the other options such as insomnia, weight loss, and increased agitation are less commonly associated with higher doses of mirtazapine. In fact, mirtazapine is often noted for its potential to promote sleep and increase appetite, which generally counters the likelihood of insomnia and weight loss occurring with higher doses.